Reference - Detail
| RRC ID | 48580 |
|---|---|
| Author | Hirano Y, Nakagawa M, Suyama T, Murase K, Shirakawa M, Takayama S, Sun TP, Hakoshima T. |
| Title | Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD. |
| Journal | Nat Plants |
| Abstract |
The plant-specific GAI, RGA and SCR (GRAS) family proteins play critical roles in plant development and signalling. Two GRAS proteins, SHORT-ROOT (SHR) and SCARECROW (SCR), cooperatively direct asymmetric cell division and the patterning of root cell types by transcriptional control in conjunction with BIRD/INDETERMINATE DOMAIN (IDD) transcription factors, although precise details of these specific interactions and actions remain unknown. Here, we present the crystal structures of the SHR-SCR binary and JACKDAW (JKD)/IDD10-SHR-SCR ternary complexes. Each GRAS domain comprises one α/β core subdomain with an α-helical cap that mediates heterodimerization by forming an intermolecular helix bundle. The α/β core subdomain of SHR forms the BIRD binding groove, which specifically recognizes the zinc fingers of JKD. We identified a conserved SHR-binding motif in 13 BIRD/IDD transcription factors. Our results establish a structural basis for GRAS-GRAS and GRAS-BIRD interactions and provide valuable clues towards our understanding of these regulators, which are involved in plant-specific signalling networks. |
| Volume | 3 |
| Pages | 17010 |
| Published | 2017-2-17 |
| DOI | 10.1038/nplants.2017.10 |
| PII | nplants201710 |
| PMID | 28211915 |
| PMC | PMC5639936 |
| MeSH | Arabidopsis / genetics* Arabidopsis / metabolism Arabidopsis Proteins / chemistry Arabidopsis Proteins / genetics* Arabidopsis Proteins / metabolism Carrier Proteins / chemistry Carrier Proteins / genetics* Carrier Proteins / metabolism Transcription Factors / chemistry Transcription Factors / genetics* Transcription Factors / metabolism |
| IF | 13.256 |
| Times Cited | 21 |
| WOS Category | PLANT SCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Arabidopsis / Cultured plant cells, genes | pda08270 pda04699 |