論文 - 詳細
| RRC ID | 48722 |
|---|---|
| 著者 | Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N, Yamasoba T. |
| タイトル | Autophagy is essential for hearing in mice. |
| ジャーナル | Cell Death Dis |
| Abstract |
Hearing loss is the most frequent sensory disorder in humans. Auditory hair cells (HCs) are postmitotic at late-embryonic differentiation and postnatal stages, and their damage is the major cause of hearing loss. There is no measurable HC regeneration in the mammalian cochlea, and the maintenance of cell function is crucial for preservation of hearing. Here we generated mice deficient in autophagy-related 5 (Atg5), a gene essential for autophagy, in the HCs to investigate the effect of basal autophagy on hearing acuity. Deletion of Atg5 resulted in HC degeneration and profound congenital hearing loss. In autophagy-deficient HCs, polyubiquitinated proteins and p62/SQSTM1, an autophagy substrate, accumulated as inclusion bodies during the first postnatal week, and these aggregates increased in number. These findings revealed that basal autophagy has an important role in maintenance of HC morphology and hearing acuity. |
| 巻・号 | 8(5) |
| ページ | e2780 |
| 公開日 | 2017-5-11 |
| DOI | 10.1038/cddis.2017.194 |
| PII | cddis2017194 |
| PMID | 28492547 |
| PMC | PMC5520715 |
| MeSH | Animals Autophagy / physiology* Autophagy-Related Protein 5 / genetics Autophagy-Related Protein 5 / metabolism* Gene Deletion Hair Cells, Auditory / cytology Hair Cells, Auditory / metabolism* Hearing / physiology* Mice Mice, Transgenic Sequestosome-1 Protein / genetics Sequestosome-1 Protein / metabolism |
| IF | 6.304 |
| 引用数 | 15 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00806 |