RRC ID 4876
Author Kose H, Yamada T, Matsumoto K.
Title OLETF allele of hyperglycemic QTL Nidd3/of is dominant.
Journal Exp. Anim.
Abstract The OLETF rat is a well-established model for the study of type 2 diabetes associated with obesity and has been shown to possess multiple hyperglycemic alleles in its genome. Here we focused on and carefully characterized one of the previously reported congenic strains, F.O-Nidd3/of that carries the OLETF allele of the Nidd3/of locus (also known as Niddm21 in the Rat Genome Database) in the normoglycemic F344 genetic background. A prominent finding was that the F1 progeny between the congenic and the F344 stain, whose genotype is heterozygote at the Nidd3/of locus, showed mild hyperglycemia equal to the parental congenic rat, suggesting that the OLETF allele is dominant. To our knowledge, this is the first study in which a diabetic QTL has been directly demonstrated to be dominant by using congenic strains.
Volume 57(2)
Pages 135-8
Published 2008-4
PII JST.JSTAGE/expanim/57.135
PMID 18421176
MeSH Alleles* Animals Carrier Proteins / genetics* Diabetes Mellitus, Type 2 / genetics Disease Models, Animal Genes, Dominant / genetics* Genome / genetics Heterozygote Hyperglycemia / genetics* Male Obesity / genetics Quantitative Trait Loci / genetics* Rats Rats, Inbred F344 Rats, Inbred OLETF / genetics*
IF 1.208
Times Cited 0