論文 - 詳細
| RRC ID | 48857 |
|---|---|
| 著者 | Herzmann S, Krumkamp R, Rode S, Kintrup C, Rumpf S. |
| タイトル | PAR-1 promotes microtubule breakdown during dendrite pruning in Drosophila. |
| ジャーナル | EMBO J |
| Abstract |
Pruning of unspecific neurites is an important mechanism during neuronal morphogenesis. Drosophila sensory neurons prune their dendrites during metamorphosis. Pruning dendrites are severed in their proximal regions. Prior to severing, dendritic microtubules undergo local disassembly, and dendrites thin extensively through local endocytosis. Microtubule disassembly requires a katanin homologue, but the signals initiating microtubule breakdown are not known. Here, we show that the kinase PAR-1 is required for pruning and dendritic microtubule breakdown. Our data show that neurons lacking PAR-1 fail to break down dendritic microtubules, and PAR-1 is required for an increase in neuronal microtubule dynamics at the onset of metamorphosis. Mammalian PAR-1 is a known Tau kinase, and genetic interactions suggest that PAR-1 promotes microtubule breakdown largely via inhibition of Tau also in Drosophila Finally, PAR-1 is also required for dendritic thinning, suggesting that microtubule breakdown might precede ensuing plasma membrane alterations. Our results shed light on the signaling cascades and epistatic relationships involved in neurite destabilization during dendrite pruning. |
| 巻・号 | 36(13) |
| ページ | 1981-1991 |
| 公開日 | 2017-7-3 |
| DOI | 10.15252/embj.201695890 |
| PII | embj.201695890 |
| PMID | 28554895 |
| PMC | PMC5494467 |
| MeSH | Animals Drosophila / physiology* Drosophila Proteins / metabolism* Epistasis, Genetic Glycogen Synthase Kinase 3 / metabolism* Microtubules / metabolism* Neuronal Plasticity* Signal Transduction |
| IF | 9.889 |
| 引用数 | 16 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 5055R‐1 |