| RRC ID |
48865
|
| Author |
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A.
|
| Title |
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.
|
| Journal |
Curr Biol
|
| Abstract |
The mechanisms by which clock neurons in the Drosophila brain confer an ∼24-hr rhythm onto locomotor activity are unclear, but involve the neuropeptide diuretic hormone 44 (DH44), an ortholog of corticotropin-releasing factor. Here we identified DH44 receptor 1 as the relevant receptor for rest:activity rhythms and mapped its site of action to hugin-expressing neurons in the subesophageal zone (SEZ). We traced a circuit that extends from Dh44-expressing neurons in the pars intercerebralis (PI) through hugin+ SEZ neurons to the ventral nerve cord. Hugin neuropeptide, a neuromedin U ortholog, also regulates behavioral rhythms. The DH44 PI-Hugin SEZ circuit controls circadian locomotor activity in a daily cycle but has minimal effect on feeding rhythms, suggesting that the circadian drive to feed can be separated from circadian locomotion. These findings define a linear peptidergic circuit that links the clock to motor outputs to modulate circadian control of locomotor activity.
|
| Volume |
27(13)
|
| Pages |
1915-1927.e5
|
| Published |
2017-7-10
|
| DOI |
10.1016/j.cub.2017.05.089
|
| PII |
S0960-9822(17)30697-8
|
| PMID |
28669757
|
| PMC |
PMC5698909
|
| MeSH |
Animals
Animals, Genetically Modified / genetics
Animals, Genetically Modified / physiology
Circadian Clocks / genetics*
Drosophila Proteins / genetics*
Drosophila Proteins / metabolism
Drosophila melanogaster / genetics
Drosophila melanogaster / physiology*
Locomotion / genetics*
Male
Neuropeptides / genetics*
Neuropeptides / metabolism
Receptors, Cell Surface / genetics*
Receptors, Cell Surface / metabolism
|
| IF |
9.601
|
| Times Cited |
22
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Drosophila |
12370R-4 |
