RRC ID 49311
Author Soyk S, Lemmon ZH, Oved M, Fisher J, Liberatore KL, Park SJ, Goren A, Jiang K, Ramos A, van der Knaap E, Van Eck J, Zamir D, Eshed Y, Lippman ZB.
Title Bypassing Negative Epistasis on Yield in Tomato Imposed by a Domestication Gene.
Journal Cell
Abstract Selection for inflorescence architecture with improved flower production and yield is common to many domesticated crops. However, tomato inflorescences resemble wild ancestors, and breeders avoided excessive branching because of low fertility. We found branched variants carry mutations in two related transcription factors that were selected independently. One founder mutation enlarged the leaf-like organs on fruits and was selected as fruit size increased during domestication. The other mutation eliminated the flower abscission zone, providing "jointless" fruit stems that reduced fruit dropping and facilitated mechanical harvesting. Stacking both beneficial traits caused undesirable branching and sterility due to epistasis, which breeders overcame with suppressors. However, this suppression restricted the opportunity for productivity gains from weak branching. Exploiting natural and engineered alleles for multiple family members, we achieved a continuum of inflorescence complexity that allowed breeding of higher-yielding hybrids. Characterizing and neutralizing similar cases of negative epistasis could improve productivity in many agricultural organisms. VIDEO ABSTRACT.
Volume 169(6)
Pages 1142-1155.e12
Published 2017-6-1
DOI 10.1016/j.cell.2017.04.032
PII S0092-8674(17)30486-5
PMID 28528644
MeSH Amino Acid Sequence Domestication Epistasis, Genetic* Inflorescence / metabolism Lycopersicon esculentum / genetics* Lycopersicon esculentum / growth & development Lycopersicon esculentum / physiology MADS Domain Proteins / chemistry MADS Domain Proteins / genetics* MADS Domain Proteins / metabolism Meristem / metabolism Plant Breeding Plant Proteins / genetics* Plant Proteins / metabolism Sequence Alignment
IF 31.398
Times Cited 1
WOS Category BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
Resource
Tomato TOMJPG5091-1