RRC ID 49316
Author Okumura K, Saito M, Yoshizawa Y, Munakata H, Isogai E, Miura I, Wakana S, Yamaguchi M, Shitara H, Taya C, Karaplis AC, Kominami R, Wakabayashi Y.
Title The parathyroid hormone regulates skin tumour susceptibility in mice.
Journal Sci Rep
Abstract ). As a result, the higher amounts of iPTH in sera conferred stronger resistance to skin tumours. Furthermore, we found that the coding SNP (rs51104087, Val28Met) localizes in the mouse Pro-PTH encoding region, which is linked to processing efficacy and increased PTH secretion. Finally, we report that PTH increases intracellular calcium in keratinocytes and promotes their terminal differentiation. Taken together, our data suggest that Pth is one of the genes responsible for Stmm1, and serum iPTH could serve as a prevention marker of skin cancer and a target for new therapies.
Volume 7(1)
Pages 11208
Published 2017-9-11
DOI 10.1038/s41598-017-11561-x
PII 10.1038/s41598-017-11561-x
PMID 28894263
PMC PMC5593851
IF 4.122
Resource
DNA material MSM/Ms Mouse BAC clone (RDB04214) MSMg01-466J23 MSMg01-047A16.