論文 - 詳細
| RRC ID | 49538 |
|---|---|
| 著者 | Matsuda R, Hosono C, Samakovlis C, Saigo K. |
| タイトル | Multipotent versus differentiated cell fate selection in the developing Drosophila airways. |
| ジャーナル | Elife |
| Abstract |
Developmental potentials of cells are tightly controlled at multiple levels. The embryonic Drosophila airway tree is roughly subdivided into two types of cells with distinct developmental potentials: a proximally located group of multipotent adult precursor cells (P-fate) and a distally located population of more differentiated cells (D-fate). We show that the GATA-family transcription factor (TF) Grain promotes the P-fate and the POU-homeobox TF Ventral veinless (Vvl/Drifter/U-turned) stimulates the D-fate. Hedgehog and receptor tyrosine kinase (RTK) signaling cooperate with Vvl to drive the D-fate at the expense of the P-fate while negative regulators of either of these signaling pathways ensure P-fate specification. Local concentrations of Decapentaplegic/BMP, Wingless/Wnt, and Hedgehog signals differentially regulate the expression of D-factors and P-factors to transform an equipotent primordial field into a concentric pattern of radially different morphogenetic potentials, which gradually gives rise to the distal-proximal organization of distinct cell types in the mature airway. |
| 巻・号 | 4 |
| 公開日 | 2015-12-2 |
| DOI | 10.7554/eLife.09646 |
| PII | e09646 |
| PMID | 26633813 |
| PMC | PMC4775228 |
| MeSH | Animals Cell Differentiation* DNA-Binding Proteins / metabolism Drosophila / embryology* Drosophila Proteins / metabolism Gene Expression Regulation POU Domain Factors / metabolism Respiratory System / embryology Transcription Factors / metabolism |
| IF | 7.08 |
| 引用数 | 2 |
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