| RRC ID |
49538
|
| 著者 |
Matsuda R, Hosono C, Samakovlis C, Saigo K.
|
| タイトル |
Multipotent versus differentiated cell fate selection in the developing Drosophila airways.
|
| ジャーナル |
Elife
|
| Abstract |
Developmental potentials of cells are tightly controlled at multiple levels. The embryonic Drosophila airway tree is roughly subdivided into two types of cells with distinct developmental potentials: a proximally located group of multipotent adult precursor cells (P-fate) and a distally located population of more differentiated cells (D-fate). We show that the GATA-family transcription factor (TF) Grain promotes the P-fate and the POU-homeobox TF Ventral veinless (Vvl/Drifter/U-turned) stimulates the D-fate. Hedgehog and receptor tyrosine kinase (RTK) signaling cooperate with Vvl to drive the D-fate at the expense of the P-fate while negative regulators of either of these signaling pathways ensure P-fate specification. Local concentrations of Decapentaplegic/BMP, Wingless/Wnt, and Hedgehog signals differentially regulate the expression of D-factors and P-factors to transform an equipotent primordial field into a concentric pattern of radially different morphogenetic potentials, which gradually gives rise to the distal-proximal organization of distinct cell types in the mature airway.
|
| 巻・号 |
4
|
| 公開日 |
2015-12-2
|
| DOI |
10.7554/eLife.09646
|
| PII |
e09646
|
| PMID |
26633813
|
| PMC |
PMC4775228
|
| MeSH |
Animals
Cell Differentiation*
DNA-Binding Proteins / metabolism
Drosophila / embryology*
Drosophila Proteins / metabolism
Gene Expression Regulation
POU Domain Factors / metabolism
Respiratory System / embryology
Transcription Factors / metabolism
|
| IF |
7.08
|
| 引用数 |
2
|
| リソース情報 |
| ショウジョウバエ |
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