RRC ID 49542
Author Hu H, Uesaka M, Guo S, Shimai K, Lu TM, Li F, Fujimoto S, Ishikawa M, Liu S, Sasagawa Y, Zhang G, Kuratani S, Yu JK, Kusakabe TG, Khaitovich P, Irie N, EXPANDE Consortium.
Title Constrained vertebrate evolution by pleiotropic genes.
Journal Nat Ecol Evol
Abstract Despite morphological diversification of chordates over 550 million years of evolution, their shared basic anatomical pattern (or 'bodyplan') remains conserved by unknown mechanisms. The developmental hourglass model attributes this to phylum-wide conserved, constrained organogenesis stages that pattern the bodyplan (the phylotype hypothesis); however, there has been no quantitative testing of this idea with a phylum-wide comparison of species. Here, based on data from early-to-late embryonic transcriptomes collected from eight chordates, we suggest that the phylotype hypothesis would be better applied to vertebrates than chordates. Furthermore, we found that vertebrates' conserved mid-embryonic developmental programmes are intensively recruited to other developmental processes, and the degree of the recruitment positively correlates with their evolutionary conservation and essentiality for normal development. Thus, we propose that the intensively recruited genetic system during vertebrates' organogenesis period imposed constraints on its diversification through pleiotropic constraints, which ultimately led to the common anatomical pattern observed in vertebrates.
Volume 1(11)
Pages 1722-1730
Published 2017-11
DOI 10.1038/s41559-017-0318-0
PII 10.1038/s41559-017-0318-0
PMID 28963548
MeSH Animals Biological Evolution* Genetic Pleiotropy* Phylogeny Vertebrates / anatomy & histology Vertebrates / genetics* Vertebrates / growth & development
IF 10.965
C.intestinalis / (O.japonicus) Wild C. int