RRC ID 4955
Author Chuang JS, Rivoire O, Leibler S.
Title Simpson's paradox in a synthetic microbial system.
Journal Science
Abstract The maintenance of "public" or "common good" producers is a major question in the evolution of cooperation. Because nonproducers benefit from the shared resource without bearing its cost of production, they may proliferate faster than producers. We established a synthetic microbial system consisting of two Escherichia coli strains of common-good producers and nonproducers. Depending on the population structure, which was varied by forming groups with different initial compositions, an apparently paradoxical situation could be attained in which nonproducers grew faster within each group, yet producers increased overall. We show that a simple way to generate the variance required for this effect is through stochastic fluctuations via population bottlenecks. The synthetic approach described here thus provides a way to study generic mechanisms of natural selection.
Volume 323(5911)
Pages 272-5
Published 2009-1-9
DOI 10.1126/science.1166739
PII 323/5911/272
PMID 19131632
MeSH 4-Butyrolactone / analogs & derivatives 4-Butyrolactone / metabolism Adaptation, Biological Chloramphenicol / pharmacology Chloramphenicol Resistance / genetics Colony Count, Microbial Culture Media Culture Media, Conditioned Escherichia coli / drug effects Escherichia coli / genetics Escherichia coli / growth & development* Escherichia coli / metabolism* Escherichia coli Proteins / metabolism Ligases / genetics Ligases / metabolism Mathematical Concepts Quorum Sensing Selection, Genetic* Stochastic Processes Systems Theory Transcription Factors / genetics Transcription Factors / metabolism
IF 41.058
Times Cited 131
Prokaryotes E. coli ME9062(BW25113) JW1901