RRC ID 49552
著者 Shimada-Niwa Y, Niwa R.
タイトル Serotonergic neurons respond to nutrients and regulate the timing of steroid hormone biosynthesis in Drosophila.
ジャーナル Nat Commun
Abstract The temporal transition of development is flexibly coordinated in the context of the nutrient environment, and this coordination is essential for organisms to increase their survival fitness and reproductive success. Steroid hormone, a key player of the juvenile-to-adult transition, is biosynthesized in a nutrient-dependent manner; however, the underlying genetic mechanism remains unclear. Here we report that the biosynthesis of insect steroid hormone, ecdysteroid, is regulated by a subset of serotonergic neurons in Drosophila melanogaster. These neurons directly innervate the prothoracic gland (PG), an ecdysteroid-producing organ and share tracts with the stomatogastric nervous system. Interestingly, the projecting neurites morphologically respond to nutrient conditions. Moreover, reduced activity of the PG-innervating neurons or of serotonin signalling in the PG strongly correlates with a delayed developmental transition. Our results suggest that serotonergic neurons form a link between the external environment and the internal endocrine system by adaptively tuning the timing of steroid hormone biosynthesis.
巻・号 5
ページ 5778
公開日 2014-12-15
DOI 10.1038/ncomms6778
PII ncomms6778
PMID 25502946
PMC PMC4284655
MeSH Animals Diet Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism* Ecdysteroids / biosynthesis* Ecdysteroids / genetics Exocrine Glands / growth & development Exocrine Glands / metabolism Gene Expression Regulation, Developmental* Genes, Reporter Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Larva / cytology Larva / growth & development Larva / metabolism* Nervous System / cytology Nervous System / growth & development Nervous System / metabolism Neurites / metabolism Neurites / ultrastructure Receptors, Serotonin / genetics Receptors, Serotonin / metabolism Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Serotonergic Neurons / metabolism* Serotonergic Neurons / ultrastructure Serotonin / metabolism Signal Transduction Time Factors
IF 12.121
引用数 34
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