論文 - 詳細
| RRC ID | 49581 |
|---|---|
| 著者 | Arata M, Sugimura K, Uemura T. |
| タイトル | Difference in Dachsous Levels between Migrating Cells Coordinates the Direction of Collective Cell Migration. |
| ジャーナル | Dev Cell |
| Abstract |
In contrast to extracellular chemotactic gradients, how cell-adhesion molecules contribute to directing cell migration remains more elusive. Here we studied the collective migration of Drosophila larval epidermal cells (LECs) along the anterior-posterior axis and propose a migrating cell group-autonomous mechanism in which an atypical cadherin Dachsous (Ds) plays a pivotal role. In each abdominal segment, the amount of Ds in each LEC varied along the axis of migration (Ds imbalance), which polarized Ds localization at cell boundaries. This Ds polarity was necessary for coordinating the migratory direction. Another atypical cadherin, Fat (Ft), and an unconventional myosin Dachs, both of which bind to Ds, also showed biased cell-boundary localizations, and both were required for the migration. Altogether, we propose that the Ds imbalance within the migrating tissue provides the directional cue and that this is decoded by Ds-Ft-mediated cell-cell contacts, which restricts lamellipodia formation to the posterior end of the cell. |
| 巻・号 | 42(5) |
| ページ | 479-497.e10 |
| 公開日 | 2017-9-11 |
| DOI | 10.1016/j.devcel.2017.08.001 |
| PII | S1534-5807(17)30629-9 |
| PMID | 28898677 |
| MeSH | Abdomen / growth & development Animals Apoptosis Body Patterning Cadherins / metabolism* Cell Movement* Cell Polarity Cell Shape Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Epidermal Cells Epidermis / metabolism Gene Knockdown Techniques Imaging, Three-Dimensional Larva / cytology Pseudopodia / metabolism |
| IF | 10.092 |
| 引用数 | 12 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |