論文 - 詳細
| RRC ID | 49588 |
|---|---|
| 著者 | Hori A, Kurata S, Kuraishi T. |
| タイトル | Unexpected role of the IMD pathway in Drosophila gut defense against Staphylococcus aureus. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
In this study, fruit fly of the genus Drosophila is utilized as a suitable model animal to investigate the molecular mechanisms of innate immunity. To combat orally transmitted pathogenic Gram-negative bacteria, the Drosophila gut is armed with the peritrophic matrix, which is a physical barrier composed of chitin and glycoproteins: the Duox system that produces reactive oxygen species (ROS), which in turn sterilize infected microbes, and the IMD pathway that regulates the expression of antimicrobial peptides (AMPs), which in turn control ROS-resistant pathogens. However, little is known about the defense mechanisms against Gram-positive bacteria in the fly gut. Here, we show that the peritrophic matrix protects Drosophila against Gram-positive bacteria S. aureus. We also define the few roles of ROS in response to the infection and show that the IMD pathway is required for the clearance of ingested microbes, possibly independently from AMP expression. These findings provide a new aspect of the gut defense system of Drosophila, and helps to elucidate the processes of gut-microbe symbiosis and pathogenesis. |
| 巻・号 | 495(1) |
| ページ | 395-400 |
| 公開日 | 2018-1-1 |
| DOI | 10.1016/j.bbrc.2017.11.004 |
| PII | S0006-291X(17)32181-2 |
| PMID | 29108998 |
| MeSH | Animals Antimicrobial Cationic Peptides / immunology Drosophila Proteins / immunology Drosophila melanogaster / immunology* Drosophila melanogaster / microbiology* Female Host-Pathogen Interactions* Immunity, Innate Male Reactive Oxygen Species / immunology Signal Transduction* Staphylococcus aureus / immunology* |
| IF | 2.985 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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| ショウジョウバエ | |