| RRC ID |
49601
|
| Author |
Nakamura YK, Janowitz C, Metea C, Asquith M, Karstens L, Rosenbaum JT, Lin P.
|
| Title |
Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine.
|
| Journal |
Sci Rep
|
| Abstract |
Short chain fatty acids (SCFA) are metabolites of intestinal bacteria resulting from fermentation of dietary fiber. SCFA are protective in various animal models of inflammatory disease. We investigated the effects of exogenous administration of SFCAs, particularly propionate, on uveitis using an inducible model of experimental autoimmune uveitis (EAU). Oral SCFA administration attenuated uveitis severity in a mouse strain-dependent manner through regulatory T cell induction among lymphocytes in the intestinal lamina propria (LPL) and cervical lymph nodes (CLN). SCFA also suppressed effector T cell induction in the CLN and mesenteric lymph nodes (MLN). Alterations in intestinal morphology and gene expression demonstrated in the EAU model prior to the onset of uveitis were blunted by oral SCFA administration. Using a Kaede transgenic mouse, we demonstrated enhanced leukocyte trafficking between the intestine and the eye in EAU. Propionate suppressed T effector cell migration between the intestine and the spleen in EAU Kaede mice. In conclusion, our findings support exogenous administration of SCFAs as a potential treatment strategy for uveitis through the stabilization of subclinical intestinal alterations that occur in inflammatory diseases including uveitis, as well as prevention of trafficking of leukocytes between the gastrointestinal tract and extra-intestinal tissues.
|
| Volume |
7(1)
|
| Pages |
11745
|
| Published |
2017-9-18
|
| DOI |
10.1038/s41598-017-12163-3
|
| PII |
10.1038/s41598-017-12163-3
|
| PMID |
28924192
|
| PMC |
PMC5603543
|
| MeSH |
Animals
Autoimmune Diseases / drug therapy*
Autoimmune Diseases / immunology
Autoimmune Diseases / pathology
Cell Movement / drug effects*
Cell Movement / immunology
Disease Models, Animal
Fatty Acids, Volatile / pharmacology*
Female
Intestines* / immunology
Intestines* / pathology
Mice
T-Lymphocytes, Regulatory* / immunology
T-Lymphocytes, Regulatory* / pathology
Uveitis* / drug therapy
Uveitis* / immunology
Uveitis* / pathology
|
| IF |
3.998
|
| Times Cited |
25
|
| Resource |
| Mice |
RBRC05737 |
