論文 - 詳細
| RRC ID | 49601 |
|---|---|
| 著者 | Nakamura YK, Janowitz C, Metea C, Asquith M, Karstens L, Rosenbaum JT, Lin P. |
| タイトル | Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine. |
| ジャーナル | Sci Rep |
| Abstract |
Short chain fatty acids (SCFA) are metabolites of intestinal bacteria resulting from fermentation of dietary fiber. SCFA are protective in various animal models of inflammatory disease. We investigated the effects of exogenous administration of SFCAs, particularly propionate, on uveitis using an inducible model of experimental autoimmune uveitis (EAU). Oral SCFA administration attenuated uveitis severity in a mouse strain-dependent manner through regulatory T cell induction among lymphocytes in the intestinal lamina propria (LPL) and cervical lymph nodes (CLN). SCFA also suppressed effector T cell induction in the CLN and mesenteric lymph nodes (MLN). Alterations in intestinal morphology and gene expression demonstrated in the EAU model prior to the onset of uveitis were blunted by oral SCFA administration. Using a Kaede transgenic mouse, we demonstrated enhanced leukocyte trafficking between the intestine and the eye in EAU. Propionate suppressed T effector cell migration between the intestine and the spleen in EAU Kaede mice. In conclusion, our findings support exogenous administration of SCFAs as a potential treatment strategy for uveitis through the stabilization of subclinical intestinal alterations that occur in inflammatory diseases including uveitis, as well as prevention of trafficking of leukocytes between the gastrointestinal tract and extra-intestinal tissues. |
| 巻・号 | 7(1) |
| ページ | 11745 |
| 公開日 | 2017-9-18 |
| DOI | 10.1038/s41598-017-12163-3 |
| PII | 10.1038/s41598-017-12163-3 |
| PMID | 28924192 |
| PMC | PMC5603543 |
| MeSH | Animals Autoimmune Diseases / drug therapy* Autoimmune Diseases / immunology Autoimmune Diseases / pathology Cell Movement / drug effects* Cell Movement / immunology Disease Models, Animal Fatty Acids, Volatile / pharmacology* Female Intestines* / immunology Intestines* / pathology Mice T-Lymphocytes, Regulatory* / immunology T-Lymphocytes, Regulatory* / pathology Uveitis* / drug therapy Uveitis* / immunology Uveitis* / pathology |
| IF | 3.998 |
| 引用数 | 25 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 23 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC05737 |