Reference - Detail
| RRC ID | 49632 |
|---|---|
| Author | Kitada S, Kayama H, Okuzaki D, Koga R, Kobayashi M, Arima Y, Kumanogoh A, Murakami M, Ikawa M, Takeda K. |
| Title | BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. |
| Journal | J Exp Med |
| Abstract |
Inappropriate IL-17 responses are implicated in chronic tissue inflammation. IL-23 contributes to Trypanosoma cruzi-specific IL-17 production, but the molecular mechanisms underlying regulation of the IL-23-IL-17 axis during T. cruzi infection are poorly understood. Here, we demonstrate a novel function of BATF2 as a negative regulator of Il23a in innate immune cells. IL-17, but not IFN-γ, was more highly produced by CD4+ T cells from spleens and livers of T. cruzi-infected Batf2-/- mice than by those of wild-type mice. In this context, Batf2-/- mice showed severe multiorgan pathology despite reduced parasite burden. T. cruzi-induced IL-23 production was increased in Batf2-/- innate immune cells. The T. cruzi-induced enhanced Th17 response was abrogated in Batf2-/-Il23a-/- mice. The interaction of BATF2 with c-JUN prevented c-JUN-ATF-2 complex formation, inhibiting Il23a expression. These results demonstrate that IFN-γ-inducible BATF2 in innate immune cells controls Th17-mediated immunopathology by suppressing IL-23 production during T. cruzi infection. |
| Volume | 214(5) |
| Pages | 1313-1331 |
| Published | 2017-5-1 |
| DOI | 10.1084/jem.20161076 |
| PII | jem.20161076 |
| PMID | 28356392 |
| PMC | PMC5413328 |
| MeSH | Animals Basic-Leucine Zipper Transcription Factors / physiology* Chagas Disease / immunology* Chagas Disease / pathology Female Immunity, Innate / immunology Interleukin-23 Subunit p19 / metabolism* Mice Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins c-jun / physiology Th17 Cells / immunology Th17 Cells / physiology* Trypanosoma cruzi / immunology* |
| IF | 10.892 |
| Times Cited | 17 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 11 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pGAL3-IL23 promoter (RDB15467) pcDNA3.1(+)_Flag-BATF2 (RDB15468). |