RRC ID 49639
Author Iwata R, Kiyonari H, Imai T.
Title Mechanosensory-Based Phase Coding of Odor Identity in the Olfactory Bulb.
Journal Neuron
Abstract Mitral and tufted (M/T) cells in the olfactory bulb produce rich temporal patterns of activity in response to different odors. However, it remains unknown how these temporal patterns are generated and how they are utilized in olfaction. Here we show that temporal patterning effectively discriminates between the two sensory modalities detected by olfactory sensory neurons (OSNs): odor and airflow-driven mechanical signals. Sniff-induced mechanosensation generates glomerulus-specific oscillatory activity in M/T cells, whose phase was invariant across airflow speed. In contrast, odor stimulation caused phase shifts (phase coding). We also found that odor-evoked phase shifts are concentration invariant and stable across multiple sniff cycles, contrary to the labile nature of rate coding. The loss of oscillatory mechanosensation impaired the precision and stability of phase coding, demonstrating its role in olfaction. We propose that phase, not rate, coding is a robust encoding strategy of odor identity and is ensured by airflow-induced mechanosensation in OSNs.
Volume 96(5)
Pages 1139-1152.e7
Published 2017-12-6
DOI 10.1016/j.neuron.2017.11.008
PII S0896-6273(17)31036-X
PMID 29216451
MeSH Absorptiometry, Photon Animals Behavior, Animal / physiology Immunohistochemistry Mechanotransduction, Cellular / physiology* Mice Neuroimaging Odorants Olfactory Bulb / physiology* Olfactory Pathways / physiology Olfactory Receptor Neurons / physiology Smell / physiology* Tracheotomy
IF 14.415
Times Cited 13
Mice RBRC02189