論文 - 詳細
| RRC ID | 50071 |
|---|---|
| 著者 | Onishi T, Sakamoto H, Namiki S, Hirose K. |
| タイトル | The Altered Supramolecular Structure of Dopamine D2 Receptors in Disc1-deficient Mice. |
| ジャーナル | Sci Rep |
| Abstract |
Disc1 is a susceptibility gene for psychiatric disorders including schizophrenia. It has been suggested that excess transmission through dopamine type 2 receptors (D2Rs) in the striatum is an underlying mechanism of pathogenesis. In this study, we used super-resolution microscopy to study the distribution of D2Rs at the nanoscale in mice lacking exons 2 and 3 of Disc1 (Disc1-deficient mice). We found that D2Rs in the nucleus accumbens (NAc) of wild-type mice form nanoclusters (~ 20,000 nm2), and that Disc1-deficient mice have larger and more D2R nanoclusters than wild-type mice. Interestingly, administration of clozapine reduced the size and spatial distribution of the nanoclusters only in Disc1-deficient mice. Moreover, we observed that medium spiny neurons in the NAc of Disc1-deficient mice had reduced spine density on their dendrites than did wild-type mice, and this was also reversed by clozapine administration. The altered D2R nanoclusters might be morphological representations of the altered dopaminergic transmission in disease states such as schizophrenia. |
| 巻・号 | 8(1) |
| ページ | 1692 |
| 公開日 | 2018-1-26 |
| DOI | 10.1038/s41598-018-20090-0 |
| PII | 10.1038/s41598-018-20090-0 |
| PMID | 29374282 |
| PMC | PMC5785963 |
| MeSH | Animals Mice Microscopy, Fluorescence Nerve Tissue Proteins / deficiency* Nucleus Accumbens / pathology* Protein Conformation Protein Multimerization* Receptors, Dopamine D2 / chemistry* Receptors, Dopamine D2 / metabolism* |
| IF | 3.998 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC03709 |