Reference - Detail
RRC ID | 50074 |
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Author | Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K. |
Title | Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury. |
Journal | Cell Stem Cell |
Abstract |
Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries. |
Volume | 22(1) |
Pages | 128-137.e9 |
Published | 2018-1-4 |
DOI | 10.1016/j.stem.2017.11.005 |
PII | S1934-5909(17)30457-5 |
PMID | 29276142 |
MeSH | Animals Animals, Newborn Brain Injuries / pathology* Brain Injuries / physiopathology* Cadherins / metabolism Cell Movement* Lateral Ventricles / pathology Neuroglia / metabolism Neuroglia / pathology* Neuroglia / ultrastructure Neurons / metabolism Neurons / pathology* Neurons / ultrastructure Recovery of Function* rhoA GTP-Binding Protein / metabolism |
IF | 20.86 |
Times Cited | 17 |
Resource | |
DNA material | pENTR4-H1 (RDB04395). |