論文 - 詳細
| RRC ID | 50315 |
|---|---|
| 著者 | Molnar C, Estrada B, de Celis JF. |
| タイトル | Tay bridge and extracellular-regulated kinase activity are required for motoneuron function in the Drosophila neural system. |
| ジャーナル | Genes Brain Behav |
| Abstract |
Extracellular regulated kinase (Erk) activity is required during neural development for the specification of cell fates in neuroblasts and neuronal lineages, and also regulates several aspects of the activity and survival of mature neurons. The activation of Erk is regulated at multiple levels by kinases and phosphatases that alter its phosphorylation state and by other proteins that regulate its subcellular localization. Here, we find that tay bridge (tay), a negative regulator of Erk in Drosophila imaginal discs, is required in the motoneurons to regulate the number and size of neuromuscular synapses in these cells. The expression of Tay is maximal in motoneurons with low levels of activated ERK, suggesting that Tay modulates the activity of Erk in these cells. We also found that loss of tay expression and increased Erk activity specifically in the motoneurons cause a reversible decrease in walking speed. Impaired motoneurons activity may be caused by alterations in the functionality and number of synaptic boutons developing at the neuromuscular junction in tay mutants. |
| 巻・号 | 17(8) |
| ページ | e12470 |
| 公開日 | 2018-11-1 |
| DOI | 10.1111/gbb.12470 |
| PMID | 29524312 |
| MeSH | Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster / genetics MAP Kinase Signaling System / physiology* Motor Neurons / metabolism* Motor Neurons / physiology Neuromuscular Junction / metabolism Neuronal Plasticity / physiology Nuclear Proteins / metabolism Nuclear Proteins / physiology* Phosphorylation Presynaptic Terminals / metabolism Signal Transduction / physiology Synapses / metabolism |
| IF | 3.397 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 10079R-2 9375R-1 |