Reference - Detail
| RRC ID | 50413 |
|---|---|
| Author | Obata F, Tsuda-Sakurai K, Yamazaki T, Nishio R, Nishimura K, Kimura M, Funakoshi M, Miura M. |
| Title | Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine. |
| Journal | Dev Cell |
| Abstract |
The intestine has direct contact with nutritional information. The mechanisms by which particular dietary molecules affect intestinal homeostasis are not fully understood. In this study, we identified S-adenosylmethionine (SAM), a universal methyl donor synthesized from dietary methionine, as a critical molecule that regulates stem cell division in Drosophila midgut. Depletion of either dietary methionine or SAM synthesis reduces division rate of intestinal stem cells. Genetic screening for putative SAM-dependent methyltransferases has identified protein synthesis as a regulator of the stem cells, partially through a unique diphthamide modification on eukaryotic elongation factor 2. In contrast, SAM in nutrient-absorptive enterocytes controls the interleukin-6-like protein Unpaired 3, which is required for rapid division of the stem cells after refeeding. Our study sheds light upon a link between diet and intestinal homeostasis and highlights the key metabolite SAM as a mediator of cell-type-specific starvation response. |
| Volume | 44(6) |
| Pages | 741-751.e3 |
| Published | 2018-3-26 |
| DOI | 10.1016/j.devcel.2018.02.017 |
| PII | S1534-5807(18)30149-7 |
| PMID | 29587144 |
| MeSH | Animals Cell Differentiation / drug effects* Cell Self Renewal / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development* Drosophila melanogaster / metabolism Enterocytes / cytology Enterocytes / drug effects Enterocytes / metabolism Female Homeostasis Interleukin-6 / metabolism Intestinal Mucosa / metabolism Intestines / cytology* Intestines / drug effects Male Methionine / deficiency Nutritional Status S-Adenosylmethionine / pharmacology* Stem Cells / cytology* Stem Cells / physiology |
| IF | 10.092 |
| Times Cited | 21 |
| Resource | |
| Drosophila | 9960R-2 |