論文 - 詳細
| RRC ID | 50489 |
|---|---|
| 著者 | Xie G, Chen H, Jia D, Shu Z, Palmer WH, Huang YC, Zeng X, Hou SX, Jiao R, Deng WM. |
| タイトル | The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in Drosophila Imaginal Tissues. |
| ジャーナル | Cancer Res |
| Abstract |
Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How SMARCB1/hSNF5 functions differently from other members of the SWI/SNF complex remains unclear. Here, we use Drosophila imaginal epithelial tissues to demonstrate that Snr1, the conserved homolog of human SMARCB1/hSNF5, prevents tumorigenesis by maintaining normal endosomal trafficking-mediated signaling cascades. Removal of Snr1 resulted in neoplastic tumorigenic overgrowth in imaginal epithelial tissues, whereas depletion of any other members of the SWI/SNF complex did not induce similar phenotypes. Unlike other components of the SWI/SNF complex that were detected only in the nucleus, Snr1 was observed in both the nucleus and the cytoplasm. Aberrant regulation of multiple signaling pathways, including Notch, JNK, and JAK/STAT, was responsible for tumor progression upon snr1-depletion. Our results suggest that the cytoplasmic Snr1 may play a tumor suppressive role in Drosophila imaginal tissues, offering a foundation for understanding the pivotal role of SMARCB1/hSNF5 in suppressing MRT during early childhood. Cancer Res; 77(4); 862-73. ©2017 AACR. |
| 巻・号 | 77(4) |
| ページ | 862-873 |
| 公開日 | 2017-2-15 |
| DOI | 10.1158/0008-5472.CAN-16-0963 |
| PII | 0008-5472.CAN-16-0963 |
| PMID | 27923836 |
| PMC | PMC7885033 |
| MeSH | Animals Drosophila Proteins / analysis Drosophila Proteins / physiology* Drosophila melanogaster Endosomes / metabolism Imaginal Discs / physiology* MAP Kinase Signaling System / physiology Receptors, Notch / physiology SMARCB1 Protein / physiology STAT Transcription Factors / physiology Signal Transduction / physiology Transcription Factors / analysis Transcription Factors / physiology* Tumor Suppressor Proteins / physiology* |
| IF | 9.727 |
| 引用数 | 6 |
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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