| RRC ID |
50530
|
| 著者 |
Inoue T, Fujii M, Kida H, Yamakawa T, Maruta Y, Tokiwa T, He Y, Nomura S, Owada Y, Yamakawa T, Suzuki M.
|
| タイトル |
Epidural focal brain cooling abolishes neocortical seizures in cats and non-human primates.
|
| ジャーナル |
Neurosci Res
|
| Abstract |
Focal brain cooling (FBC) is under investigation in preclinical trials of intractable epilepsy (IE), including status epilepticus (SE). This method has been studied in rodents as a possible treatment for epileptic disorders, but more evidence from large animal studies is required. To provide evidence that FBC is a safe and effective therapy for IE, we investigated if FBC using a titanium cooling plate can reduce or terminate focal neocortical seizures without having a significant impact on brain tissue. Two cats and two macaque monkeys were chronically implanted with an epidural FBC device over the somatosensory and motor cortex. Penicillin G was delivered via the intracranial cannula for induction of local seizures. Repetitive FBC was performed using a cooling device implanted for a medium-term period (FBC for 30min at least twice every week; 3 months total) in three of the four animals. The animals exhibited seizures with repetitive epileptiform discharges (EDs) after administration of penicillin G, and these discharges decreased at less than 20°C cooling with no adverse histological effects. The results of this study suggest that epidural FBC is a safe and effective potential treatment for IE and SE.
|
| 巻・号 |
122
|
| ページ |
35-44
|
| 公開日 |
2017-9-1
|
| DOI |
10.1016/j.neures.2017.04.007
|
| PII |
S0168-0102(17)30234-1
|
| PMID |
28450153
|
| MeSH |
Animals
Cats
Disease Models, Animal
Electrocorticography
Epilepsy / chemically induced
Epilepsy / physiopathology
Epilepsy / therapy*
Female
Hypothermia, Induced* / adverse effects
Hypothermia, Induced* / instrumentation
Hypothermia, Induced* / methods
Macaca
Male
Motor Cortex / physiopathology*
|
| IF |
2.645
|
| 引用数 |
7
|
| リソース情報 |
| ニホンザル |
|
