論文 - 詳細
| RRC ID | 50530 |
|---|---|
| 著者 | Inoue T, Fujii M, Kida H, Yamakawa T, Maruta Y, Tokiwa T, He Y, Nomura S, Owada Y, Yamakawa T, Suzuki M. |
| タイトル | Epidural focal brain cooling abolishes neocortical seizures in cats and non-human primates. |
| ジャーナル | Neurosci Res |
| Abstract |
Focal brain cooling (FBC) is under investigation in preclinical trials of intractable epilepsy (IE), including status epilepticus (SE). This method has been studied in rodents as a possible treatment for epileptic disorders, but more evidence from large animal studies is required. To provide evidence that FBC is a safe and effective therapy for IE, we investigated if FBC using a titanium cooling plate can reduce or terminate focal neocortical seizures without having a significant impact on brain tissue. Two cats and two macaque monkeys were chronically implanted with an epidural FBC device over the somatosensory and motor cortex. Penicillin G was delivered via the intracranial cannula for induction of local seizures. Repetitive FBC was performed using a cooling device implanted for a medium-term period (FBC for 30min at least twice every week; 3 months total) in three of the four animals. The animals exhibited seizures with repetitive epileptiform discharges (EDs) after administration of penicillin G, and these discharges decreased at less than 20°C cooling with no adverse histological effects. The results of this study suggest that epidural FBC is a safe and effective potential treatment for IE and SE. |
| 巻・号 | 122 |
| ページ | 35-44 |
| 公開日 | 2017-9-1 |
| DOI | 10.1016/j.neures.2017.04.007 |
| PII | S0168-0102(17)30234-1 |
| PMID | 28450153 |
| MeSH | Animals Cats Disease Models, Animal Electrocorticography Epilepsy / chemically induced Epilepsy / physiopathology Epilepsy / therapy* Female Hypothermia, Induced* / adverse effects Hypothermia, Induced* / instrumentation Hypothermia, Induced* / methods Macaca Male Motor Cortex / physiopathology* |
| IF | 2.645 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニホンザル | |