論文 - 詳細
| RRC ID | 50641 |
|---|---|
| 著者 | Saito K, Koike T, Kawashima F, Kurata H, Shibuya T, Satoh T, Hata Y, Yamada H, Mori T. |
| タイトル | Identification of NeuN immunopositive cells in the adult mouse subventricular zone. |
| ジャーナル | J Comp Neurol |
| Abstract |
In the adult rodent subventricular zone (SVZ), there are neural stem cells (NSCs) and the specialized neurogenic niche is critical to maintain their stemness. To date, many cellular and noncellular factors that compose the neurogenic niche and markers to identify subpopulations of Type A cells have been confirmed. In particular, neurotransmitters regulate adult neurogenesis and mature neurons in the SVZ have been only partially analyzed. Moreover, Type A cells, descendants of NSCs, are highly heterogeneous and more molecular markers are still needed to identify them. In the present study, we systematically classified NeuN, commonly used as a marker of mature and immature post-mitotic neurons, immunopositive (+) cells within the adult mouse SVZ. These SVZ-NeuN+ cells (SVZ-Ns) were mainly classified into two types. One was mature SVZ-Ns (M-SVZ-Ns). Neurochemical properties of M-SVZ-Ns were similar to those of striatal neurons, but their birth date and morphology were different. M-SVZ-Ns were generated during embryonic and early postnatal stages with bipolar peaks and extended their processes along the wall of the lateral ventricle. The second type was small SVZ-Ns (S-SVZ-Ns) with features of Type A cells. They expressed not only markers of Type A cells, but also proliferated and migrated from the SVZ to the olfactory bulb. Furthermore, S-SVZ-Ns could be classified into two types by their spatial locations and glutamic acid decarboxylase 67 expression. Our data indicate that M-SVZ-Ns are a new component of the neurogenic niche and S-SVZ-Ns are newly identified subpopulations of Type A cells. |
| 巻・号 | 526(12) |
| ページ | 1927-1942 |
| 公開日 | 2018-8-15 |
| DOI | 10.1002/cne.24463 |
| PMID | 29752725 |
| MeSH | Animals Biomarkers / analysis DNA-Binding Proteins Lateral Ventricles / cytology* Male Mice Mice, Inbred C57BL Mice, Inbred ICR Nerve Tissue Proteins / analysis* Neural Stem Cells / cytology* Neurogenesis / physiology Neurons / cytology* Nuclear Proteins / analysis* Stem Cell Niche* |
| IF | 3.4 |
| 引用数 | 3 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC03674 |