Reference - Detail
| RRC ID | 50814 |
|---|---|
| Author | Aoki R, Kamikado K, Suda W, Takii H, Mikami Y, Suganuma N, Hattori M, Koga Y. |
| Title | A proliferative probiotic Bifidobacterium strain in the gut ameliorates progression of metabolic disorders via microbiota modulation and acetate elevation. |
| Journal | Sci Rep |
| Abstract |
The gut microbiota is an important contributor to the worldwide prevalence of metabolic syndrome (MS), which includes obesity and diabetes. The anti-MS effects exerted by Bifidobacterium animalis ssp. lactis GCL2505 (BlaG), a highly proliferative Bifidobacterium strain in the gut, and B. longum ssp. longum JCM1217T (BloJ) were comparatively examined. BlaG treatment reduced visceral fat accumulation and improved glucose tolerance, whereas BloJ had no effect on these parameters. Gut microbial analysis revealed that BlaG exerted stronger effects on the overall bacterial structure of the gut microbiota than BloJ, including enrichment of the genus Bifidobacterium. The levels of acetate and glucagon-like peptide-1 were increased by BlaG treatment in both the gut and plasma, but not by BloJ treatment. Correlation analysis suggested that the elevation of gut acetate levels by BlaG treatment plays a pivotal role in the BlaG-induced anti-MS effects. These findings indicated that BlaG, a highly viable and proliferative probiotic, improves metabolic disorders by modulating gut microbiota, which results in the elevation of SCFAs, especially acetate. |
| Volume | 7 |
| Pages | 43522 |
| Published | 2017-3-2 |
| DOI | 10.1038/srep43522 |
| PII | srep43522 |
| PMID | 28252037 |
| PMC | PMC5333160 |
| MeSH | Acetates / metabolism* Animals Bifidobacterium / metabolism* Disease Models, Animal Gastrointestinal Microbiome* Glucose / metabolism Glucose Intolerance / metabolism Glucose Intolerance / therapy Male Metabolic Diseases / etiology Metabolic Diseases / metabolism* Metabolic Diseases / therapy Metagenome Metagenomics / methods Mice Probiotics* |
| IF | 3.998 |
| Times Cited | 43 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 87 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| General Microbes | JCM 1217 |