| RRC ID |
50828
|
| Author |
Maeda K, Nakajima Y, Tanahashi Y, Kitou Y, Miwa A, Kanamaru K, Kobayashi T, Nishiuchi T, Kimura M.
|
| Title |
L-Threonine and its analogue added to autoclaved solid medium suppress trichothecene production by Fusarium graminearum.
|
| Journal |
Arch Microbiol
|
| Abstract |
Fusarium graminearum produces trichothecene mycotoxins under certain nutritional conditions. When L-Thr and its analogue L-allo-threonine were added to brown rice flour solid medium before inoculation, trichothecene production after 4 days of incubation was suppressed. A time-course analysis of gene expression demonstrated that L-Thr suppressed transcription of Tri6, a trichothecene master regulator gene, and a terpene cyclase Tri5 gene. Regulation of trichothecene biosynthesis by altering major primary metabolic processes may open up the possibility to develop safe chemicals for the reduction of mycotoxin contamination might be developed.
|
| Volume |
199(6)
|
| Pages |
945-952
|
| Published |
2017-8-1
|
| DOI |
10.1007/s00203-017-1364-3
|
| PII |
10.1007/s00203-017-1364-3
|
| PMID |
28357472
|
| MeSH |
Culture Media / chemistry*
Culture Media / metabolism
Fusarium / chemistry
Fusarium / genetics
Fusarium / growth & development
Fusarium / metabolism*
Gene Expression
Gene Expression Regulation, Fungal
Hot Temperature
Mycotoxins / biosynthesis*
Oryza / microbiology
Threonine / chemistry
Threonine / metabolism*
Trichothecenes / biosynthesis*
|
| IF |
1.884
|
| Times Cited |
4
|
| Resource |
| General Microbes |
JCM 9873 |
