RRC ID 50870
Author Kato K, Odamaki T, Mitsuyama E, Sugahara H, Xiao JZ, Osawa R.
Title Age-Related Changes in the Composition of Gut Bifidobacterium Species.
Journal Curr Microbiol
Abstract Bifidobacteria are one of the major components in human microbiota that are suggested to function in maintaining human health. The colonization and cell number of Bifidobacterium species in human intestine vary with ageing. However, sequential changes of Bifidobacterium species ranging from newborns to centenarians remain unresolved. Here, we investigated the gut compositional changes of Bifidobacterium species over a wide range of ages. Faecal samples of 441 healthy Japanese subjects between the ages of 0 and 104 years were analysed using real-time PCR with species-specific primers. B. longum group was widely detected from newborns to centenarians, with the highest detection rate. B. breve was detected in approximately 70% of children under 3 years old. B. adolescentis and B. catenulatum groups were predominant after weaning. B. bifidum was detected at almost all ages. The detection rate of B. dentium was higher in the elderly than in other ages. B. animalis ssp. lactis was detected in 11.4% of the subjects and their ages were restricted. B. gallinarum goup was detected in only nine subjects, while B. minimum and B. mongoliense were undetected at any age. The presence of certain Bifidobacterium groups was associated with significantly higher numbers of other Bifidobacterium species/subspecies. Inter-species correlations were found among each species, exception for B. animalis ssp. lactis. These results revealed the patterns and transition points with respect to compositional changes of Bifidobacterium species that occur with ageing, and the findings indicate that there may be symbiotic associations between some of these species in the gut microbiota.
Volume 74(8)
Pages 987-995
Published 2017-8-1
DOI 10.1007/s00284-017-1272-4
PII 10.1007/s00284-017-1272-4
PMID 28593350
PMC PMC5486783
MeSH Adolescent Adult Age Factors Aged Aged, 80 and over Aging* Bifidobacterium / classification* Bifidobacterium / isolation & purification* Child Child, Preschool Feces / microbiology Female Gastrointestinal Microbiome* Gastrointestinal Tract / microbiology* Healthy Volunteers Humans Infant Infant, Newborn Japan Male Middle Aged Real-Time Polymerase Chain Reaction Young Adult
IF 1.746
Times Cited 31
General Microbes JCM 1275 JCM 1190 JCM 1255 JCM 1192 JCM 1195 JCM 6291 JCM 1217 JCM 5821 JCM 15461 JCM 1200