論文 - 詳細
| RRC ID | 50946 |
|---|---|
| 著者 | Tawthep S, Fukiya S, Lee JY, Hagio M, Ogura Y, Hayashi T, Yokota A. |
| タイトル | Isolation of six novel 7-oxo- or urso-type secondary bile acid-producing bacteria from rat cecal contents. |
| ジャーナル | J Biosci Bioeng |
| Abstract |
Understanding the dynamics of secondary bile acid (SBA) formation in the gut by SBA-producing bacteria is important for host health, as SBAs have been shown to affect host pathophysiology and gut microbiota composition. However, our knowledge of SBA producers is limited in light of the diversity of gut microbes. Here, we isolated six novel SBA-producing bacteria from rat cecal contents, all of which were members of known species of gut microbes. Anaerostipes caccae D10, Bacteroides nordii C5, Clostridioides difficile D7, and Clostridium cadaveris G11 were capable of oxidizing cholic acid and chenodeoxycholic acid into 7-oxo-derivatives with varying yields. B. nordii C5 and its type strain JCM 12987T had the highest molar yield, ∼90%. Clostridium disporicum F4 and Clostridium subterminale C4 epimerized cholic acid into ursocholic acid with yields of ∼85%; the corresponding type strains lacked epimerization activity. Furthermore, although not novel as an SBA producer, Clostridium scindens G10 that produced deoxycholic acid from cholic acid was isolated for the first time from rodents. These findings will contribute to elucidation of SBA formation in the gut. |
| 巻・号 | 124(5) |
| ページ | 514-522 |
| 公開日 | 2017-11-1 |
| DOI | 10.1016/j.jbiosc.2017.06.002 |
| PII | S1389-1723(17)30334-1 |
| PMID | 28751127 |
| MeSH | Animals Bacteria / isolation & purification* Bacteria / metabolism* Bacteroides / isolation & purification Bacteroides / metabolism Bile Acids and Salts / biosynthesis* Cecum / microbiology* Chenodeoxycholic Acid / metabolism Cholic Acid / metabolism Cholic Acids / metabolism Clostridium / isolation & purification Clostridium / metabolism Deoxycholic Acid / metabolism Male Rats |
| IF | 2.366 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 12987 JCM 13470 JCM 1296 JCM 1392 JCM 6567 JCM 1417 JCM 1401 |