Reference - Detail
| RRC ID | 51164 |
|---|---|
| Author | Sugiyama Y, Nara M, Sakanaka M, Gotoh A, Kitakata A, Okuda S, Kurihara S. |
| Title | Comprehensive analysis of polyamine transport and biosynthesis in the dominant human gut bacteria: Potential presence of novel polyamine metabolism and transport genes. |
| Journal | Int J Biochem Cell Biol |
| Abstract |
Recent studies have reported that polyamines in the colonic lumen might affect animal health and these polyamines are thought to be produced by gut bacteria. In the present study, we measured the concentrations of three polyamines (putrescine, spermidine, and spermine) in cells and culture supernatants of 32 dominant human gut bacterial species in their growing and stationary phases. Combining polyamine concentration analysis in culture supernatant and cells with available genomic information showed that novel polyamine biosynthetic proteins and transporters were present in dominant human gut bacteria. Based on these findings, we suggested strategies for optimizing polyamine concentrations in the human colonic lumen via regulation of genes responsible for polyamine biosynthesis and transport in the dominant human gut bacteria. |
| Volume | 93 |
| Pages | 52-61 |
| Published | 2017-12-1 |
| DOI | 10.1016/j.biocel.2017.10.015 |
| PII | S1357-2725(17)30282-0 |
| PMID | 29102547 |
| MeSH | Bacteria / genetics Bacteria / metabolism* Bacterial Proteins / genetics Bacterial Proteins / metabolism* Biogenic Polyamines / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism* Colon / metabolism Colon / microbiology* Gastrointestinal Microbiome / physiology* Humans |
| IF | 3.673 |
| Times Cited | 12 |
| Altmetric score |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
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