RRC ID 51291
Author Matsuda K, Yoshida M, Kawakami K, Hibi M, Shimizu T.
Title Granule cells control recovery from classical conditioned fear responses in the zebrafish cerebellum.
Journal Sci Rep
Abstract indicator GCaMP7a in cerebellar neurons. The botulinum-toxin-dependent inhibition of granule-cell transmissions in the corpus cerebelli (CCe, the medial lobe) did not suppress the CS-evoked bradycardia response, but rather prolonged the response. We identified cerebellar neurons with elevated CS-evoked activity after the conditioning. The CS-evoked activity of these neurons was progressively upregulated during the conditioning and was downregulated with repetition of the unpaired CS. Some of these neurons were activated immediately upon the CS presentation, whereas others were activated after a delay. Our findings indicate that granule cells control the recovery from conditioned fear responses in zebrafish.
Volume 7(1)
Pages 11865
Published 2017-9-19
DOI 10.1038/s41598-017-10794-0
PII 10.1038/s41598-017-10794-0
PMID 28928404
PMC PMC5605521
IF 4.122
Zebrafish Tg(huC:GVP)