Reference - Detail
| RRC ID | 51388 |
|---|---|
| Author | Zhou K, Cherra SJ 3rd, Goncharov A, Jin Y. |
| Title | Asynchronous Cholinergic Drive Correlates with Excitation-Inhibition Imbalance via a Neuronal Ca2+ Sensor Protein. |
| Journal | Cell Rep |
| Abstract |
Excitation-inhibition imbalance in neural networks is widely linked to neurological and neuropsychiatric disorders. However, how genetic factors alter neuronal activity, leading to excitation-inhibition imbalance, remains unclear. Here, using the C. elegans locomotor circuit, we examine how altering neuronal activity for varying time periods affects synaptic release pattern and animal behavior. We show that while short-duration activation of excitatory cholinergic neurons elicits a reversible enhancement of presynaptic strength, persistent activation results to asynchronous and reduced cholinergic drive, inducing imbalance between endogenous excitation and inhibition. We find that the neuronal calcium sensor protein NCS-2 is required for asynchronous cholinergic release in an activity-dependent manner and dampens excitability of inhibitory neurons non-cell autonomously. The function of NCS-2 requires its Ca2+ binding and membrane association domains. These results reveal a synaptic mechanism implicating asynchronous release in regulation of excitation-inhibition balance. |
| Volume | 19(6) |
| Pages | 1117-1129 |
| Published | 2017-5-9 |
| DOI | 10.1016/j.celrep.2017.04.043 |
| PII | S2211-1247(17)30537-5 |
| PMID | 28494862 |
| PMC | PMC5510947 |
| MeSH | Animals Binding Sites Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans / physiology Calcium / metabolism Cholinergic Neurons / metabolism* Cholinergic Neurons / physiology Excitatory Postsynaptic Potentials* Inhibitory Postsynaptic Potentials* Neuronal Calcium-Sensor Proteins / chemistry Neuronal Calcium-Sensor Proteins / genetics Neuronal Calcium-Sensor Proteins / metabolism* Protein Binding |
| IF | 8.109 |
| Times Cited | 6 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1943 |