Reference - Detail
| RRC ID | 51409 |
|---|---|
| Author | Sinclair J, Pinter K, Samuel T, Beardsley S, Yuan X, Zhang J, Meng K, Yun S, Krause M, Hamza I. |
| Title | Inter-organ signalling by HRG-7 promotes systemic haem homeostasis. |
| Journal | Nat Cell Biol |
| Abstract |
Growing evidence in vertebrates predicts that cellular haem levels in animals are maintained not only by a cell's internal capacity for haem synthesis in a cell-autonomous manner, but also by an inter-organ haem trafficking network through cell-non-autonomous regulation. Using Caenorhabditis elegans, a genetically and optically amenable animal model for visualizing haem-dependent signalling, we show that HRG-7, a protein with homology to aspartic proteases, mediates inter-organ signalling between the intestine and extra-intestinal tissues. Intestinal HRG-7 functions as a secreted signalling factor during haem starvation in extra-intestinal tissues and is regulated through a DBL-1, homologous to BMP5, dependent signal from neurons. Given the evidence that vertebrate homologues exist for each of the components of the HRG-7-mediated signalling pathway, it is conceivable that the cell-non-autonomous signalling framework that we uncovered in C. elegans may have functional relevance for inter-organ regulation of iron and haem metabolism in humans. |
| Volume | 19(7) |
| Pages | 799-807 |
| Published | 2017-7-1 |
| DOI | 10.1038/ncb3539 |
| PII | ncb3539 |
| PMID | 28581477 |
| PMC | PMC5594749 |
| MeSH | Animals Animals, Genetically Modified Biological Transport Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism Gene Expression Regulation Heme / deficiency Heme / metabolism* Hemeproteins / genetics Hemeproteins / metabolism* Homeostasis Intestinal Mucosa / metabolism* Neurons / metabolism Neuropeptides / genetics Neuropeptides / metabolism RNA Interference Signal Transduction* Time Factors Transcription Factors / genetics Transcription Factors / metabolism Transforming Growth Factor beta / genetics Transforming Growth Factor beta / metabolism |
| IF | 20.042 |
| Times Cited | 8 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm6801 |