論文 - 詳細
| RRC ID | 51444 |
|---|---|
| 著者 | Zhao L, Rui Q, Wang D. |
| タイトル | Molecular basis for oxidative stress induced by simulated microgravity in nematode Caenorhabditis elegans. |
| ジャーナル | Sci Total Environ |
| Abstract |
Caenorhabditis elegans is an important in vivo assay system for toxicological studies. Herein, we investigated the role of oxidative stress and the underlying molecular mechanism for induced adverse effects of simulated microgravity. In nematodes, simulated microgravity treatment induced a significant induction of oxidative stress. Genes (mev-1, gas-1, and isp-1) encoding a molecular machinery for the control of oxidative stress were found to be dysregulated in simulated microgravity treated nematodes. Meanwhile, genes (sod-2, sod-3, sod-4, sod-5, aak-2, skn-1, and gst-4) encoding certain antioxidant defense systems were increased in simulated microgravity treated nematodes. Mutation of mev-1, gas-1, sod-2, sod-3, aak-2, skn-1, or gst-4 enhanced susceptibility to oxidative stress induced by simulated microgravity, whereas mutation of isp-1 induced a resistance to oxidative stress induced by simulated microgravity. Mutation of sod-2, sod-3, or aak-2 further suppressed the recovery effect of simulated microgravity toxicity in nematodes after simulated microgravity treatment for 1h. Moreover, administration of ascorbate could inhibit the adverse effects including the induction of oxidative stress in simulated microgravity treated nematodes. Mutation of any of the genes encoding metallothioneins or the genes of hsp-16.1, hsp-16.2 and hsp-16.48 encoding heat-shock proteins did not affect the induction of oxidative stress in simulated microgravity treated nematodes. Our results provide a molecular basis for the induction of oxidative stress in simulated microgravity treated organisms. |
| 巻・号 | 607-608 |
| ページ | 1381-1390 |
| 公開日 | 2017-12-31 |
| DOI | 10.1016/j.scitotenv.2017.07.088 |
| PII | S0048-9697(17)31792-8 |
| PMID | 28738528 |
| MeSH | Animals Antioxidants Caenorhabditis elegans / physiology* Gene Expression Regulation Genes, Helminth* Oxidative Stress* Weightlessness* |
| IF | 6.551 |
| 引用数 | 19 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1770 |