論文 - 詳細
| RRC ID | 51479 |
|---|---|
| 著者 | Adachi T, Nagahama K, Izumi S. |
| タイトル | The C. elegans mRNA decapping enzyme shapes morphology of cilia. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Cilia and flagella are evolutionarily conserved organelles that protrude from cell surfaces. Most cilia and flagella are single rod-shaped but some cilia show a variety of shapes. For example, human airway epithelial cells are multiciliated, flagella of crayfish spermatozoon are star-like shaped, and fruit fly spermatozoon extends long flagella. In Caenorhabditis elegans, cilia display morphological diversity of shapes (single, dual rod-type and wing-like and highly-branched shapes). Here we show that DCAP-1 and DCAP-2, which are the homologues of mammalian DCP1 and DCP2 mRNA decapping enzymes, respectively, are involved in formation of dual rod-type and wing-like shaped cilia in C. elegans. mRNA decapping enzyme catalyzes hydrolysis of 5' cap structure of mRNA, which leads to degradation of mRNA. Rescue experiments showed that DCAP-2 acts not in glial cells surrounding cilia but in neurons. This is the first evidence to demonstrate that mRNA decapping is involved in ciliary shape formation. |
| 巻・号 | 493(1) |
| ページ | 382-387 |
| 公開日 | 2017-11-4 |
| DOI | 10.1016/j.bbrc.2017.09.014 |
| PII | S0006-291X(17)31768-0 |
| PMID | 28887031 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / enzymology* Cell Shape / physiology* Cilia / enzymology* Cilia / ultrastructure* Endoribonucleases / metabolism* Neurons / enzymology Neurons / ultrastructure* |
| IF | 2.985 |
| 引用数 | 0 |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3163 |