論文 - 詳細
| RRC ID | 51497 |
|---|---|
| 著者 | Hong M, Ryu L, Ow MC, Kim J, Je AR, Chinta S, Huh YH, Lee KJ, Butcher RA, Choi H, Sengupta P, Hall SE, Kim K. |
| タイトル | Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans. |
| ジャーナル | Curr Biol |
| Abstract |
Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3-7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses. |
| 巻・号 | 27(20) |
| ページ | 3168-3177.e3 |
| 公開日 | 2017-10-23 |
| DOI | 10.1016/j.cub.2017.08.068 |
| PII | S0960-9822(17)31108-9 |
| PMID | 28988862 |
| PMC | PMC5805149 |
| MeSH | Animals Avoidance Learning Caenorhabditis elegans / physiology* Hermaphroditic Organisms / physiology Memory* Pheromones / physiology* Sensory Receptor Cells / physiology* Signal Transduction |
| IF | 9.601 |
| 引用数 | 7 |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm718 |