RRC ID 51497
Author Hong M, Ryu L, Ow MC, Kim J, Je AR, Chinta S, Huh YH, Lee KJ, Butcher RA, Choi H, Sengupta P, Hall SE, Kim K.
Title Early Pheromone Experience Modifies a Synaptic Activity to Influence Adult Pheromone Responses of C. elegans.
Journal Curr Biol
Abstract Experiences during early development can influence neuronal functions and modulate adult behaviors [1, 2]. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The C. elegans ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites [3-7]. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure [8]. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the odr-2 glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses.
Volume 27(20)
Pages 3168-3177.e3
Published 2017-10-23
DOI 10.1016/j.cub.2017.08.068
PII S0960-9822(17)31108-9
PMID 28988862
PMC PMC5805149
MeSH Animals Avoidance Learning Caenorhabditis elegans / physiology* Hermaphroditic Organisms / physiology Memory* Pheromones / physiology* Sensory Receptor Cells / physiology* Signal Transduction
IF 9.601
Times Cited 7
C.elegans tm718