論文 - 詳細
| RRC ID | 51528 |
|---|---|
| 著者 | Sood P, Murthy K, Kumar V, Nonet ML, Menon GI, Koushika SP. |
| タイトル | Cargo crowding at actin-rich regions along axons causes local traffic jams. |
| ジャーナル | Traffic |
| Abstract |
Steady axonal cargo flow is central to the functioning of healthy neurons. However, a substantial fraction of cargo in axons remains stationary up to several minutes. We examine the transport of precursors of synaptic vesicles (pre-SVs), endosomes and mitochondria in Caenorhabditis elegans touch receptor neurons, showing that stationary cargo are predominantly present at actin-rich regions along the neuronal process. Stationary vesicles at actin-rich regions increase the propensity of moving vesicles to stall at the same location, resulting in traffic jams arising from physical crowding. Such local traffic jams at actin-rich regions are likely to be a general feature of axonal transport since they also occur in Drosophila neurons. Repeated touch stimulation of C. elegans reduces the density of stationary pre-SVs, indicating that these traffic jams can act as both sources and sinks of vesicles. This suggests that vesicles trapped in actin-rich regions are functional reservoirs that may contribute to maintaining robust cargo flow in the neuron. A video abstract of this article can be found at: Video S1; Video S2. |
| 巻・号 | 19(3) |
| ページ | 166-181 |
| 公開日 | 2018-3-1 |
| DOI | 10.1111/tra.12544 |
| PMID | 29178177 |
| MeSH | Actins / metabolism Animals Axonal Transport* Caenorhabditis elegans Drosophila Endosomes / metabolism Mitochondria / metabolism Synaptic Vesicles / metabolism |
| IF | 4.045 |
| 引用数 | 8 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 35 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1552 |