論文 - 詳細
| RRC ID | 51542 |
|---|---|
| 著者 | E L, Zhou T, Koh S, Chuang M, Sharma R, Pujol N, Chisholm AD, Eroglu C, Matsunami H, Yan D. |
| タイトル | An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection. |
| ジャーナル | Neuron |
| Abstract |
Infections have been identified as possible risk factors for aging-related neurodegenerative diseases, but it remains unclear whether infection-related immune molecules have a causative role in neurodegeneration during aging. Here, we reveal an unexpected role of an epidermally expressed antimicrobial peptide, NLP-29 (neuropeptide-like protein 29), in triggering aging-associated dendrite degeneration in C. elegans. The age-dependent increase of nlp-29 expression is regulated by the epidermal tir-1/SARM-pmk-1/p38 MAPK innate immunity pathway. We further identify an orphan G protein-coupled receptor NPR-12 (neuropeptide receptor 12) acting in neurons as a receptor for NLP-29 and demonstrate that the autophagic machinery is involved cell autonomously downstream of NPR-12 to transduce degeneration signals. Finally, we show that fungal infections cause dendrite degeneration using a similar mechanism as in aging, through NLP-29, NPR-12, and autophagy. Our findings reveal an important causative role of antimicrobial peptides, their neuronal receptors, and the autophagy pathway in aging- and infection-associated dendrite degeneration. |
| 巻・号 | 97(1) |
| ページ | 125-138.e5 |
| 公開日 | 2018-1-3 |
| DOI | 10.1016/j.neuron.2017.12.001 |
| PII | S0896-6273(17)31124-8 |
| PMID | 29301098 |
| PMC | PMC5757245 |
| MeSH | Aging / immunology Aging / metabolism* Aging / pathology Animals Antimicrobial Cationic Peptides / metabolism* Autophagy / physiology Caenorhabditis elegans Dendrites / metabolism Dendrites / pathology* Mycoses / immunology Mycoses / pathology Nerve Degeneration / immunology Nerve Degeneration / metabolism* Rats Receptors, G-Protein-Coupled / metabolism |
| IF | 14.415 |
| 引用数 | 9 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 33 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1498 tm1931 |