論文 - 詳細
| RRC ID | 51556 |
|---|---|
| 著者 | Kim KW, Tang NH, Andrusiak MG, Wu Z, Chisholm AD, Jin Y. |
| タイトル | A Neuronal piRNA Pathway Inhibits Axon Regeneration in C. elegans. |
| ジャーナル | Neuron |
| Abstract |
The PIWI-interacting RNA (piRNA) pathway has long been thought to function solely in the germline, but evidence for its functions in somatic cells is emerging. Here we report an unexpected role for the piRNA pathway in Caenorhabditis elegans sensory axon regeneration after injury. Loss of function in a subset of components of the piRNA pathway results in enhanced axon regrowth. Two essential piRNA factors, PRDE-1 and PRG-1/PIWI, inhibit axon regeneration in a gonad-independent and cell-autonomous manner. By smFISH analysis we find that prde-1 transcripts are present in neurons, as well as germ cells. The piRNA pathway inhibits axon regrowth independent of nuclear transcriptional silencing but dependent on the slicer domain of PRG-1/PIWI, suggesting that post-transcriptional gene silencing is involved. Our results reveal the neuronal piRNA pathway as a novel intrinsic repressor of axon regeneration. |
| 巻・号 | 97(3) |
| ページ | 511-519.e6 |
| 公開日 | 2018-2-7 |
| DOI | 10.1016/j.neuron.2018.01.014 |
| PII | S0896-6273(18)30017-5 |
| PMID | 29395906 |
| PMC | PMC5866297 |
| MeSH | Animals Argonaute Proteins / metabolism* Axons / metabolism* Caenorhabditis elegans Caenorhabditis elegans Proteins / metabolism* Germ Cells / metabolism RNA, Small Interfering / metabolism* Regeneration* Signal Transduction |
| IF | 14.415 |
| 引用数 | 18 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 27 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1116 tm1200 tm1489 tm2252 tm3748 tm4477 tm6145 tm6424 tm869 tm872 |