RRC ID 51567
著者 Venero Galanternik M, Castranova D, Gore AV, Blewett NH, Jung HM, Stratman AN, Kirby MR, Iben J, Miller MF, Kawakami K, Maraia RJ, Weinstein BM.
タイトル A novel perivascular cell population in the zebrafish brain.
ジャーナル Elife
Abstract The blood-brain barrier is essential for the proper homeostasis and function of the CNS, but its mechanism of function is poorly understood. Perivascular cells surrounding brain blood vessels are thought to be important for blood-brain barrier establishment, but their roles are not well defined. Here, we describe a novel perivascular cell population closely associated with blood vessels on the zebrafish brain. Based on similarities in their morphology, location, and scavenger behavior, these cells appear to be the zebrafish equivalent of cells variably characterized as Fluorescent Granular Perithelial cells (FGPs), perivascular macrophages, or 'Mato Cells' in mammals. Despite their macrophage-like morphology and perivascular location, zebrafish FGPs appear molecularly most similar to lymphatic endothelium, and our imaging studies suggest that these cells emerge by differentiation from endothelium of the optic choroidal vascular plexus. Our findings provide the first report of a perivascular cell population in the brain derived from vascular endothelium.
巻・号 6
公開日 2017-4-11
DOI 10.7554/eLife.24369
PII e24369
PMID 28395729
PMC PMC5423774
MeSH Animals Blood Vessels / cytology* Blood-Brain Barrier / cytology* Brain / cytology* Cell Differentiation Endothelial Cells / cytology* Zebrafish*
IF 7.08
引用数 31
リソース情報
ゼブラフィッシュ gSAlzGFFD478A