RRC ID 51620
Author Shi YH, Zhu S, Tamura T, Kadowaki M, Wang Z, Yoshimatsu K, Komatsu K.
Title Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora.
Journal J Nat Med
Abstract The methanolic extract and its subfractions from the dried root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora Pallas, showed potent anti-allergic effect as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 26 compounds, including a new norneolignan glycoside, paeonibenzofuran (1), together with 25 known ones (2-26). The chemical structure of the new compound was elucidated on the basis of spectroscopic and chemical evidences. Among the isolated compounds, mudanpioside E (5) with paeoniflorin-type skeleton and quercetin (16) showed potent inhibitory activity against a degranulation marker, β-hexosaminidase release with IC50 values of 40.34 and 25.05 μM, respectively. A primary structure-activity relationship of these components was discussed.
Volume 70(2)
Pages 234-40
Published 2016-4-1
DOI 10.1007/s11418-016-0966-4
PII 10.1007/s11418-016-0966-4
PMID 26833191
MeSH Animals Anti-Allergic Agents / isolation & purification Anti-Allergic Agents / pharmacology* Biomarkers / metabolism Bridged-Ring Compounds / analysis Cell Line, Tumor Glucosides / isolation & purification Glucosides / pharmacology Glycosides / pharmacology Mast Cells / drug effects* Mast Cells / metabolism Monoterpenes / isolation & purification Monoterpenes / pharmacology Paeonia / chemistry* Paeonia / classification Phytotherapy Plant Extracts / chemistry Plant Extracts / pharmacology* Plant Roots / chemistry Quercetin / isolation & purification Quercetin / pharmacology Rats Species Specificity Structure-Activity Relationship beta-N-Acetylhexosaminidases / metabolism
IF 2.055
Times Cited 2
Human and Animal Cells RBL 2H3(RCB2782)