論文 - 詳細
| RRC ID | 51646 |
|---|---|
| 著者 | Amen YM, Zhu Q, Tran HB, Afifi MS, Halim AF, Ashour A, Mira A, Shimizu K. |
| タイトル | Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells. |
| ジャーナル | J Nat Med |
| Abstract |
A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compounds were evaluated against human colorectal carcinoma (HCT-116, Caco-2), human liver carcinoma (HepG2), and human cervical carcinoma (HeLa) cell lines using WST-1 reagent. Selectivity was evaluated using normal human fibroblast cells (TIG-1 and HF19). Among the compounds, lucidumol C showed potent selective cytotoxicity against HCT-116 cells with an IC50 value of 7.86 ± 4.56 µM and selectivity index (SI) >10 with remarkable cytotoxic activities against Caco-2, HepG2 and HeLa cell lines. |
| 巻・号 | 70(3) |
| ページ | 661-6 |
| 公開日 | 2016-7-1 |
| DOI | 10.1007/s11418-016-0976-2 |
| PII | 10.1007/s11418-016-0976-2 |
| PMID | 26899240 |
| MeSH | Cell Line, Tumor Drugs, Chinese Herbal / therapeutic use* Ganoderma / chemistry* HeLa Cells Humans Lanosterol / analogs & derivatives* Lanosterol / chemistry Neoplasms / drug therapy* Reishi / chemistry* |
| IF | 2.055 |
| 引用数 | 14 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CACO-2(RCB0988) |