論文 - 詳細
| RRC ID | 51652 |
|---|---|
| 著者 | Li Y, Takahashi Y, Fujii S, Zhou Y, Hong R, Suzuki A, Tsubata T, Hase K, Wang JY. |
| タイトル | EAF2 mediates germinal centre B-cell apoptosis to suppress excessive immune responses and prevent autoimmunity. |
| ジャーナル | Nat Commun |
| Abstract |
Regulated apoptosis of germinal centre (GC) B cells is critical for normal humoral immune responses. ELL-associated factor 2 (EAF2) regulates transcription elongation and has been shown to be an androgen-responsive potential tumour suppressor in prostate by inducing apoptosis. Here we show that EAF2 is selectively upregulated in GC B cells among various immune cell types and promotes apoptosis of GC B cells both in vitro and in vivo. EAF2 deficiency results in enlarged GCs and elevated antibody production during a T-dependent immune response. After immunization with type II collagen, mice lacking EAF2 produce high levels of collagen-specific autoantibodies and rapidly develop severe arthritis. Moreover, the mutant mice spontaneously produce anti-dsDNA, rheumatoid factor and anti-nuclear antibodies as they age. These results demonstrate that EAF2-mediated apoptosis in GC B cells limits excessive humoral immune responses and is important for maintaining self-tolerance. |
| 巻・号 | 7 |
| ページ | 10836 |
| 公開日 | 2016-3-3 |
| DOI | 10.1038/ncomms10836 |
| PII | ncomms10836 |
| PMID | 26935903 |
| PMC | PMC4782062 |
| MeSH | Animals Apoptosis / physiology* Autoimmunity / physiology* B-Lymphocytes / physiology* Gene Expression Regulation / physiology* Mice Nuclear Proteins / genetics Nuclear Proteins / metabolism* Peyer's Patches / cytology Spleen / cytology Trans-Activators / genetics Trans-Activators / metabolism* |
| IF | 12.121 |
| 引用数 | 11 |
| リソース情報 | |
| ヒト・動物細胞 | HEp-2(RCB1889) |