論文 - 詳細
| RRC ID | 51673 |
|---|---|
| 著者 | Wang X, Li X, Yoshiyuki K, Watanabe Y, Sogo Y, Ohno T, Tsuji NM, Ito A. |
| タイトル | Comprehensive Mechanism Analysis of Mesoporous-Silica-Nanoparticle-Induced Cancer Immunotherapy. |
| ジャーナル | Adv Healthc Mater |
| Abstract |
A plain mesoporous silica nanoparticle without any immunomodulatory molecules significantly enhances anticancer immunity in vivo. Comprehensive mechanism of mesoporous-silica-nanoparticle-induced cancer immunotherapy is analyzed in this paper. The mesoporous silica nanoparticle promotes both Th1 and Th2 immune responses, as it accelerates lymphocytes proliferation, stimulates IFN-γ, IL-2, IL-4, and IL-10 cytokine secretion by lymphocytes ex vivo, and increases IgG, IgG1, IgG2a, IgM, and IgA antibody titers in mice serum compared with those of alum and adjuvant-free groups. Moreover, the mesoporous silica nanoparticle enhances effector memory CD4(+) and CD8(+) T cell populations in three most important immune organs (bone marrow, lymph node, and spleen) of mice compared with those of alum and adjuvant-free groups three months after adjuvant injection. The present study paves the way for the application of mesoporous silica nanoparticle as immunoadjuvant for cancer immunotherapy. |
| 巻・号 | 5(10) |
| ページ | 1169-76 |
| 公開日 | 2016-5-1 |
| DOI | 10.1002/adhm.201501013 |
| PMID | 26987867 |
| MeSH | Adjuvants, Immunologic / administration & dosage Animals Bone Marrow / drug effects Bone Marrow / immunology CD4-Positive T-Lymphocytes / drug effects CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / drug effects CD8-Positive T-Lymphocytes / immunology Cell Proliferation / drug effects Female Immunoglobulins / immunology Immunologic Memory / drug effects Immunologic Memory / immunology Immunotherapy / methods Interferon-gamma / immunology Interleukins / immunology Lymph Nodes / drug effects Lymph Nodes / immunology Lymphocytes / drug effects Lymphocytes / immunology Mice Mice, Inbred C57BL Nanoparticles / administration & dosage* Neoplasms / immunology* Neoplasms / therapy* Silicon Dioxide / administration & dosage* Silicon Dioxide / immunology* Spleen / drug effects Spleen / immunology Th1 Cells / drug effects Th1 Cells / immunology Th2 Cells / drug effects Th2 Cells / immunology |
| IF | 7.367 |
| 引用数 | 28 |
| リソース情報 | |
| ヒト・動物細胞 | LLC(RCB0558) |