RRC ID 5169
Author Ryan KA, Daly P, Li Y, Hooton C, O'Toole PW.
Title Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli.
Journal J. Antimicrob. Chemother.
Abstract OBJECTIVES:To investigate the anti-Helicobacter pylori activity of 28 strains of Lactobacillus salivarius and 12 other lactobacilli, isolated from different sites and from different geographical regions.
METHODS:An in vitro agar plate diffusion assay was employed to assess the Lactobacillus anti-H. pylori activity.
RESULTS:Nine out of 28 L. salivarius strains and 3/12 other Lactobacillus species tested inhibited H. pylori growth. There was no correlation between ecological niche/geographical location of isolation of the lactobacilli and their inhibitory capability. Further studies on strain L. salivarius UCC119 showed that this strain could inhibit growth of 6/6 clinical isolates of H. pylori, five of which were antibiotic-resistant. This inhibition was not due to acid production and was not mediated by a protein, but did require the presence of live cells.
CONCLUSIONS:Growth inhibition of H. pylori by L. salivarius is strain-dependent and is not linked to any particular environmental niche or geographic location. Strains of L. salivarius showing highest anti-H. pylori activity may be useful as an adjunct in the treatment of strains that are resistant to conventional antibiotics.
Volume 61(4)
Pages 831-4
Published 2008-4
DOI 10.1093/jac/dkn040
PII dkn040
PMID 18263567
MeSH Antibiosis* Bacterial Proteins / metabolism Culture Media / chemistry Helicobacter Infections / microbiology Helicobacter pylori / growth & development* Humans Hydrogen-Ion Concentration Lactobacillus / physiology*
IF 5.113
Times Cited 38
WOS Category PHARMACOLOGY & PHARMACY INFECTIOUS DISEASES MICROBIOLOGY
Resource
General Microbes JCM1040 JCM1042 JCM1045 JCM1046 JCM1047 JCM1230