論文 - 詳細
RRC ID | 5169 |
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著者 | Ryan KA, Daly P, Li Y, Hooton C, O'Toole PW. |
タイトル | Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli. |
ジャーナル | J Antimicrob Chemother |
Abstract |
OBJECTIVES:To investigate the anti-Helicobacter pylori activity of 28 strains of Lactobacillus salivarius and 12 other lactobacilli, isolated from different sites and from different geographical regions. METHODS:An in vitro agar plate diffusion assay was employed to assess the Lactobacillus anti-H. pylori activity. RESULTS:Nine out of 28 L. salivarius strains and 3/12 other Lactobacillus species tested inhibited H. pylori growth. There was no correlation between ecological niche/geographical location of isolation of the lactobacilli and their inhibitory capability. Further studies on strain L. salivarius UCC119 showed that this strain could inhibit growth of 6/6 clinical isolates of H. pylori, five of which were antibiotic-resistant. This inhibition was not due to acid production and was not mediated by a protein, but did require the presence of live cells. CONCLUSIONS:Growth inhibition of H. pylori by L. salivarius is strain-dependent and is not linked to any particular environmental niche or geographic location. Strains of L. salivarius showing highest anti-H. pylori activity may be useful as an adjunct in the treatment of strains that are resistant to conventional antibiotics. |
巻・号 | 61(4) |
ページ | 831-4 |
公開日 | 2008-4-1 |
DOI | 10.1093/jac/dkn040 |
PII | dkn040 |
PMID | 18263567 |
MeSH | Antibiosis* Bacterial Proteins / metabolism Culture Media / chemistry Helicobacter Infections / microbiology Helicobacter pylori / growth & development* Humans Hydrogen-Ion Concentration Lactobacillus / physiology* |
IF | 5.439 |
引用数 | 45 |
WOS 分野 | PHARMACOLOGY & PHARMACY INFECTIOUS DISEASES MICROBIOLOGY |
リソース情報 | |
一般微生物 | JCM1040 JCM1042 JCM1045 JCM1046 JCM1047 JCM1230 |