論文 - 詳細
| RRC ID | 51691 |
|---|---|
| 著者 | Darwish AG, Samy MN, Sugimoto S, Otsuka H, Abdel-Salam H, Matsunami K. |
| タイトル | Effects of Hepatoprotective Compounds from the Leaves of Lumnitzera racemosa on Acetaminophen-Induced Liver Damage in Vitro. |
| ジャーナル | Chem Pharm Bull (Tokyo) |
| Abstract |
Phytochemical investigation of the n-BuOH fraction of the mangrove plant Lumnitzera racemosa WILLD. (Combretaceae) led to the isolation of one new flavonoid glycoside; myrcetin 3-O-methyl glucuronate (1), one new phenolic glycoside; lumniracemoside (2) and one new aliphatic alcohol glycoside; n-hexanol 1-O-rutinoside (3), in addition to seven known compounds (4-10). The structures of these compounds were determined by spectroscopic analyses (UV, IR, high resolution-electrospray ionization (HR-ESI)-MS, one- and two-dimensional (1D- and 2D)-NMR). Compound 7 showed the highest hepatoprotective activity against acetaminophen-induced hepatotoxicity using human HepG2 cells at protection % value of 34.2±3.1%, while compounds 1, 2, 3, 6, and 9 showed weak to moderate hepatoprotective activity (11.6-18.9%). Almost all of these compounds showed stronger 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity compared with the standard Trolox. These results suggest the usefulness of this plant extract and the isolated compounds as promising hepatoprotective agents. |
| 巻・号 | 64(4) |
| ページ | 360-5 |
| 公開日 | 2016-1-1 |
| DOI | 10.1248/cpb.c15-00830 |
| PMID | 27039833 |
| MeSH | Acetaminophen / toxicity* Chemical and Drug Induced Liver Injury / prevention & control* Combretaceae / chemistry* Hep G2 Cells Humans In Vitro Techniques Liver / drug effects* Magnetic Resonance Spectroscopy Plant Extracts / isolation & purification Plant Extracts / pharmacology* Plant Leaves / chemistry* Spectroscopy, Fourier Transform Infrared |
| IF | 1.416 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2(RCB1886) |