論文 - 詳細
| RRC ID | 51715 |
|---|---|
| 著者 | Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. |
| タイトル | Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. |
| ジャーナル | Nat Microbiol |
| Abstract |
Microbial proteases degrade a variety of host proteins(1-3). However, it has remained largely unknown why microorganisms have evolved to acquire such proteases and how the host responds to microbially degraded products. Here, we have found that immunoglobulins disrupted by microbial pathogens are specifically detected by leukocyte immunoglobulin-like receptor A2 (LILRA2), an orphan activating receptor expressed on human myeloid cells. Proteases from Mycoplasma hyorhinis, Legionella pneumophila, Streptococcus pneumonia and Candida albicans cleaved the N-terminus of immunoglobulins. Identification of the immunoglobulin-cleaving protease from L. pneumophila revealed that the protease is conserved across some bacteria including Vibrio spp. and Pseudomonas aeruginosa. These microbially cleaved immunoglobulins but not normal immunoglobulins stimulated human neutrophils via LILRA2. In addition, stimulation of primary monocytes via LILRA2 inhibited the growth of L. pneumophila. When mice were infected with L. pneumophila, immunoglobulins were cleaved and recognized by LILRA2. More importantly, cleaved immunoglobulins were detected in patients with bacterial infections and stimulated LILRA2-expressing cells. Our findings demonstrate that LILRA2 is a type of innate immune receptor in the host immune system that detects immunoglobulin abnormalities caused by microbial pathogens. |
| 巻・号 | 1(6) |
| ページ | 16054 |
| 公開日 | 2016-4-25 |
| DOI | 10.1038/nmicrobiol.2016.54 |
| PII | nmicrobiol201654 |
| PMID | 27572839 |
| MeSH | Animals Bacteria / enzymology* Bacteria / metabolism Cytokines / metabolism Humans Immunity, Innate Immunoglobulins / metabolism* Immunoglobulins / pharmacology Legionella pneumophila / drug effects Legionella pneumophila / enzymology Legionella pneumophila / growth & development Legionella pneumophila / immunology Legionnaires' Disease Mice Monocytes / drug effects Monocytes / microbiology Mycoplasma hyorhinis / enzymology Neutrophils / drug effects Peptide Hydrolases / metabolism* Receptors, Immunologic / immunology* Receptors, Immunologic / metabolism Streptococcus pneumoniae / enzymology |
| IF | 15.54 |
| 引用数 | 12 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 52 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |