| RRC ID |
51723
|
| Author |
Narukawa Y, Komatsu C, Yamauchi R, Shibayama S, Hachisuka M, Kiuchi F.
|
| Title |
Two new lignans and melanogenesis inhibitors from Schisandra nigra.
|
| Journal |
J Nat Med
|
| Abstract |
An acetone extract from the stems of Schisandra nigra MAX. (Schisandraceae) exhibited significant inhibition of 3-isobutyl-1-methylxanthine (IBMX)-stimulated melanogenesis in murine B16 melanoma F10 cells. Fractionation and purification of the extract led to the isolation of two new tetrahydrofuran-type lignans, (+)-5-methoxyzuonin A (2) and kadlongirin C (3), along with eight known compounds (1, 4-10). The structures of the new compounds were determined by spectroscopic analyses. Of the isolated compounds (1, 3 -10), (+)-zuonin A (1) showed remarkable inhibition of melanogenesis at concentrations without cytotoxicity in B16 melanoma F10 cells. (+)-Zuonin A (1) did not inhibit tyrosinase; however, Western blot analysis revealed that it decreased protein levels of tyrosinase and tyrosinase-related proteins (TRP)-1 and TRP-2 without changing phosphorylation level of cAMP response element-binding protein.
|
| Volume |
70(3)
|
| Pages |
460-6
|
| Published |
2016-7-1
|
| DOI |
10.1007/s11418-016-1000-6
|
| PII |
10.1007/s11418-016-1000-6
|
| PMID |
27142263
|
| MeSH |
Animals
Cell Line, Tumor
Lignans / metabolism*
Melanins / metabolism*
Mice
Molecular Structure
Schisandra / chemistry*
|
| IF |
2.055
|
| Times Cited |
4
|
| Resource |
| Human and Animal Cells |
MKN74(RCB1002) |
