Reference - Detail
| RRC ID | 51725 |
|---|---|
| Author | Widyowati R, Sugimoto S, Yamano Y, Sukardiman, Otsuka H, Matsunami K. |
| Title | New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica. |
| Journal | Chem Pharm Bull (Tokyo) |
| Abstract |
Three new flavonoid glycosides named isolinariins C, D and E (1-3), two known flavonoid glycosides (4, 5) and three known flavonoids (6-8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC50 values of 34.8, 35.0 and 19.5 µM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC50 values of 79.4, 78.6 and 40.5 µM, respectively, without significant cytotoxicity at these concentrations. |
| Volume | 64(5) |
| Pages | 517-21 |
| Published | 2016-1-1 |
| DOI | 10.1248/cpb.c16-00073 |
| PMID | 27150486 |
| MeSH | Cell Proliferation / drug effects Collagenases / metabolism Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Flavonoids / chemistry Flavonoids / isolation & purification Flavonoids / pharmacology* Glycation End Products, Advanced / metabolism* Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology* Humans Inhibitory Concentration 50 Linaria / chemistry* Matrix Metalloproteinase Inhibitors / chemistry Matrix Metalloproteinase Inhibitors / isolation & purification Matrix Metalloproteinase Inhibitors / pharmacology* Molecular Structure Structure-Activity Relationship Tumor Cells, Cultured |
| IF | 1.416 |
| Times Cited | 7 |
| Resource | |
| Human and Animal Cells | MKN74(RCB1002) |