| RRC ID |
51782
|
| Author |
Arai M, Kamiya K, Shin D, Matsumoto H, Hisa T, Setiawan A, Kotoku N, Kobayashi M.
|
| Title |
N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.
|
| Journal |
Chem Pharm Bull (Tokyo)
|
| Abstract |
In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC50 value of 16 µM, whereas no growth-inhibition was observed up to 100 µM under the general culture conditions.
|
| Volume |
64(7)
|
| Pages |
766-71
|
| Published |
2016-1-1
|
| DOI |
10.1248/cpb.c16-00118
|
| PMID |
27373630
|
| MeSH |
Alkynes / chemistry
Alkynes / isolation & purification
Alkynes / pharmacology*
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Indonesia
Molecular Structure
Pyridines / chemistry
Pyridines / isolation & purification
Pyridines / pharmacology*
Structure-Activity Relationship
Tumor Cells, Cultured
Xestospongia / chemistry*
|
| IF |
1.416
|
| Times Cited |
13
|
| Resource |
| Human and Animal Cells |
PANC-1(RCB2095) |
