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RRC ID 51877
著者 Takase F, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, Ueda Y, Kokubu T, Kurosaka M.
タイトル Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: In vitro and in vivo evaluations.
ジャーナル J Orthop Res
Abstract Atrophy with fatty degeneration is often seen in rotator cuff muscles with torn tendons. PRP has been reported to enhance tissue repair processes after tendon ruptures. However, the effect of PRP on atrophy and fatty degeneration of the muscle is not yet known. The aim of this study is to examine the effect of PRP on degeneration change of rotator cuff muscles in vitro and in vivo. A murine myogenic cell line and a rat rotator cuff tear model were used in this study and PRP was administrated into subacromial space which is widely used in clinical practice. In in vitro study, administration of PRP to C2C12 cells stimulated cell proliferation while inhibited both myogenic and adipogenic differentiation. In in vivo study, administration of PRP suppressed Oil Red-O positive lipid droplet formation. The expression of adipogenic genes was also decreased by PRP administration. In conclusion, PRP promoted proliferation of myoblast cells, while inhibiting adipogenic differentiation of myoblast cells and suppressing fatty degeneration change in rat torn rotator cuff muscles. Further investigations are needed to determine the clinical applicability of the PRP. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1806-1815, 2017.
巻・号 35(8)
ページ 1806-1815
公開日 2017-8-1
DOI 10.1002/jor.23451
PMID 27684960
MeSH Adipogenesis* Adult Animals Azo Compounds Cell Line Cell Proliferation Cell Shape Healthy Volunteers Humans Male Mice Muscle Development* Muscular Atrophy / etiology Muscular Atrophy / therapy* Platelet-Rich Plasma* Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction Rotator Cuff Injuries / complications Rotator Cuff Injuries / therapy*
IF 3.414
引用数 9
リソース情報
ヒト・動物細胞 C2C12(RCB0987)