| RRC ID |
51893
|
| Author |
Kaynak Bayrak G, Demirtaş TT, Gümüşderelioğlu M.
|
| Title |
Microwave-induced biomimetic approach for hydroxyapatite coatings of chitosan scaffolds.
|
| Journal |
Carbohydr Polym
|
| Abstract |
Simulated body fluid (SBF) can form calcium phosphates on osteoinductive materials, so it is widely used for coating of bone scaffolds to mimic natural extracellular matrix (ECM). However, difficulties of bulk coating in 3D scaffolds and the necessity of long process times are the common problems for coating with SBF. In the present study, a microwave-assisted process was developed for rapid and internal coating of chitosan scaffolds. The scaffolds were fabricated as superporous hydrogel (SPH) by combining microwave irradiation and gas foaming methods. Then, they were immersed into 10x SBF-like solution and homogenous bone-like hydroxyapatite (HA) coating was achieved by microwave treatment at 600W without the need of any nucleating agent. Cell culture studies with MC3T3-E1 preosteoblasts showed that microwave-assisted biomimetic HA coating process could be evaluated as an efficient and rapid method to obtain composite scaffolds for bone tissue engineering.
|
| Volume |
157
|
| Pages |
803-813
|
| Published |
2017-2-10
|
| DOI |
10.1016/j.carbpol.2016.10.016
|
| PII |
S0144-8617(16)31175-4
|
| PMID |
27987994
|
| MeSH |
Biomimetic Materials
Biomimetics
Bone Substitutes / chemistry*
Chitosan / chemistry*
Durapatite / chemistry*
Microwaves*
Tissue Engineering
Tissue Scaffolds*
|
| IF |
7.182
|
| Times Cited |
26
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
